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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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21 hot topic(s) found with the query "Gene drive"

Biotech firm announces results from first US trial of genetically modified mosquitoes Oxitec reports that its insects behaved as planned — but a larger trial is needed to learn whether they can reduce wild mosquito populations.
E Waltz, Nature, April 18, 2022 (Posted: Apr 19, 2022 7AM)

Gene drives gaining speed
E Bier, Nature Rev Genetics, August 6, 2021 (Posted: Aug 09, 2021 0AM)

Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne diseases, crop pests and non-native invasive species. However, concerns have been raised regarding the potential unintended impacts of gene-drive systems.

How An Altered Strand Of DNA Can Cause Malaria-Spreading Mosquitoes To Self-Destruct
R Stein, NPR, July 28, 2021 (Posted: Jul 28, 2021 10AM)

The male mosquitoes were engineered with a sequence of DNA known as a "gene drive" that can rapidly transmit a deleterious mutation that essentially wipes out populations of the insects. The goal is to create a powerful new tool to fight malaria, which remains one of the world's most terrible scourges.

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
A Hammond et al, Nature Communication, July 28, 2021 (Posted: Jul 28, 2021 10AM)

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles gambiae effectively suppressed the reproductive capability of mosquito populations reared in small laboratory cages. To bridge the gap between laboratory and the field, this gene-drive technology must be challenged with vector ecology. Here we report the suppressive activity of the gene-drive in age-structured An. gambiae populations in indoor cages that permit feeding and reproductive behaviors.

First genetically modified mosquitoes released in the United States
E Watz, Nature News, May 4, 2021 (Posted: May 05, 2021 7AM)

After a decade of fighting for regulatory approval and public acceptance, a biotechnology firm has released genetically engineered mosquitoes into the open air in the United States for the first time. The experiment, launched this week in the Florida Keys tests a method for suppressing populations of wild Aedes aegypti mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever.

750 million genetically engineered mosquitoes approved for release in Florida Keys
S LaMotte, CNN, August 19, 2020 (Posted: Aug 20, 2020 7AM)

The Gene Drive Dilemma: We Can Alter Entire Species, but Should We?
J Kahn, NY Times, January 8, 2020 (Posted: Jan 09, 2020 8AM)

A new genetic engineering technology could help eliminate malaria and stave off extinctions — if humanity decides to unleash it.

See A Controversial Swarm Of Genetically Modified Mosquitoes In A Lab In Italy
NPR, October 20. 2019 (Posted: Oct 22, 2019 9AM)

An international team of scientists is conducting a controversial experiment in Italy. The experiment is designed to test genetically modified mosquitoes that researchers hope could provide a powerful new weapon to fight malaria, which remains one of the world's greatest scourges.

Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population.
Evans Benjamin R et al. Scientific reports 2019 Sep (1) 13047 (Posted: Sep 15, 2019 8AM)

To control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing a dominant lethal gene has been developed. Approximately 450 thousand males of this strain were released each week for 27 months in Jacobina, Bahia, Brazil.

Ban on ‘gene drives’ is back on the UN’s agenda — worrying scientists
E Callaway, Nature, November 16, 2018 (Posted: Nov 16, 2018 2PM)

The promise and peril of gene drives- A new genetic-engineering technology should be used with care
The Economist, November 8, 2018 (Posted: Nov 12, 2018 0PM)

Scientists use gene drive to eradicate lab mosquitoes for the first time
I Swetlitz, Stat News, September 24, 2018 (Posted: Sep 25, 2018 9AM)

Informed consent in field trials of gene-drive mosquitoes.
Kolopack Pamela A et al. Gates open research 2017 Dec 14 (Posted: Feb 16, 2018 1PM)

Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods.
Benedict Mark Q et al. Vector borne and zoonotic diseases (Larchmont, N.Y.) 2017 Oct (Posted: Nov 13, 2017 9AM)

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.
Hammond Andrew M et al. PLoS genetics 2017 Oct (10) e1007039 (Posted: Oct 10, 2017 10AM)

The gene drive bubble: New realities
JJ Bull et al, PLOS Genetics, July 2017 (Posted: Aug 13, 2017 8PM)

This new gene technology could wipe out entire species — to save others
C Harvey, Washington Post, September 7, 2016 (Posted: Sep 08, 2016 7AM)

National Academies Hit the Brakes on Gene Drive–Modified Organisms
J Abbasi, JAMA, August 2, 2016 (Posted: Aug 03, 2016 7AM)

"Gene drive." Learn the term. Because it could one day transform the world.
B Plumer, VOX, June 2016 (Posted: Jun 10, 2016 7AM)

Gene Drive Research Takes Aim at Malaria
Francis Collins, NIH Director, December 1, 2015 Brand (Posted: Dec 01, 2015 0PM)

'Gene drive' mosquitoes engineered to fight malaria Mutant mozzies could rapidly spread through wild populations.
H Ledford, Nature News, November 23, 2015 (Posted: Nov 24, 2015 9AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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